Run for ALD, Cure the Boys
Typically 36–53°F · some rain risk
See last 10 years
On this date: rain 3 of the last 10 years
2025
50–57°F
rain
2024
36–44°F
dry
2023
41–49°F
dry
2022
28–52°F
dry
2021
42–58°F
dry
2020
45–51°F
rain
2019
42–63°F
rain
2018
30–53°F
dry
2017
33–54°F
dry
2016
31–48°F
dry
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About this race
10th Anniversary
Run for ALD, Cure the Boys!
Nov. 21st, 2026
Join Knockout ALD for a milestone year! We are proud to host the 10th Anniversary Run for ALD, the only homegrown event of its kind in the St. Louis area dedicated to raising vital awareness and funds for adrenoleukodystrophy (ALD). Whether you join us in person or participate virtually from anywhere in the world on your own time, your steps help us Cure the Boys.
Event Details
Date: Saturday, November 21st, 2026
Time: 9:00 AM
In-Person Location: Creve Coeur Park (near St. Louis, MO)
Virtual Option: Participate from wherever you are, on your own schedule!
Deadlines & Perks
Free Event T-Shirt: Included with both in-person and virtual registrations!
T-Shirt Deadline: You must register by October 21st to guarantee your shirt.
Form a Team!
Our teams are an important part of our mission and are key to raising awareness and funds. During registration, you will have the option to easily create or join a team to rally your friends, family, and coworkers!
Why We Move: About ALD & Our Mission
• What is ALD? Adrenoleukodystrophy (ALD) is a progressive, rare genetic disease that affects about 1 in 15,000 people worldwide. It progressively damages the adrenal glands, spinal cord, and myelin of the nervous system. It most severely affects boys, some of whom suffer severe neurological symptoms that can result in death if the disease is undiagnosed and not treated very early.
• Our "Why" : This event is inspired by the vision of our son, Nicholas, who underwent a successful bone marrow transplant to halt the progression of his cerebral ALD at the University of Minnesota Children's Hospital (a world leader in ALD treatment).
100% of the funds raised from this event go directly to the University of Minnesota Leukodystrophy Center for ALD Research. Your support funds early identification, more effective therapies, treatment options, and hopefully, one day, a cure.
Support the Cause (Beyond Registration) - The majority of our impact comes from donations above and beyond race registrations. If you cannot participate, or if you want to make an even bigger difference, please consider supporting us in one of these ways:
- Add a donation: You can add a donation directly during registration.
- Direct Donation: Use the "Donate" tab on this page to give without registering.
- Donate by Check: To help us avoid online processing fees, you can mail a check directly to:
Knockout ALD
1551 Timberlake Manor Parkway
Chesterfield, MO 63017
THANK YOU for helping us champion this cause for a decade. Let's Knockout ALD together!
Course map
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